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Proteins Membrane Binding and Pore Formation

There are currently only two structures of pores available, of alpha-toxin fromStaphylococcus aureus and hemolysin E from Escherichia coli. So what we know about these proteins was obtained over many years of intense experimentation. We have nevertheless, in the last couple of years, witnessed a significant rise in structural information on the soluble forms of pore-forming proteins. Surprisingly, many unexpected similarities with other proteins were noted, despite extremely low or insignificant sequence similarity. It appears that lipid membrane binding and formation of transmembrane channels is achieved in many cases by a limited repertoire of structures. This book describes how several of the important pore forming toxin families achieve membrane binding and which structural elements are used for formation of transmembrane pores. Our contributors have thus provided the means for a comparative analysis of several unrelated families.

Proteins Membrane Binding and Pore Formation
Series: Advances in Experimental Medicine and Biology, Vol. 677
Anderluh, Gregor; Lakey, Jeremy H. (Eds.)
Springer, New York ISBN: 978-1-4419-6326-0

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Book Chapters

  1. Anderluh G, Menestrina G (2001) Pore-forming proteins from sea anemones and the construction of immunotoxins for selective killing of harmful cells. In: Recent advances in marine biotechnology. Vol. 6, Bio-organic compounds: chemistry and biomedical applications (Fingerman M, Nagabhushanam R, eds.). Enfield; Plymouth: Science Publishers, Inc., pages 131-148.
  2. Anderluh G, Maček P (2003) Actinoporins, pore-forming toxins of sea anemones (Actiniara). In: Pore-forming peptides and protein toxins: Cellular and molecular mechanisms of toxin action (Menestrina G, Dalla Serra M, eds.). London; New York: Taylor and Francis, pages 132-147. 
  3. Anderluh G, Lakey JH (2005) Lipid interactions of alpha-helical protein toxins. In: Protein-lipid interactions: from membrane domains to cellular networks (Tamm, LK, ed.). Weinheim: Wiley-VCH, pages 141-162. 
  4. Lakey JH, Anderluh G (2010) Membrane disrupting proteins. In: Handbook of hydrocarbon and lipid microbiology (Timmis, KW, ed.). Berlin; Heidelberg: Springer, pages 425-433.
  5. Bakrač B, Anderluh G (2010) Molecular mechanism of sphingomyelin-specific membrane binding and pore formation by actinoporins. In: Proteins membrane binding and pore formation (Advances in experimental medicine and biology, Vol. 677) (Anderluh G, Lakey JH, eds.). New York: Springer, 2010, pages 106-115. 
  6. Podlesnik Beseničar M, Anderluh G (2010) Preparation of lipid membrane surfaces for molecular interaction studies by surface plasmon resonance biosensors. In: Surface plasmon resonance : methods and protocols, (Methods in molecular biology, vol. 627) (De Mol NJ, Fischer MJE, eds.). New York: Springer, pages 191-200. 
  7. Hodnik V, Anderluh G (2010) Capture of intact liposomes in Biacore sensor chips for protein-membrane interaction studies. In: Surface plasmon resonance : methods and protocols, (Methods in molecular biology, vol. 627) (De Mol NJ, Fischer MJE, eds.). New York: Springer, pages 201-211.