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BOOKS

Pore Formation by MAPCF/CDC proteins- Agents of Defence, Attack and Invasion

Rezultat iskanja slik za MACPF/CDC proteins

MACPF/CDC superfamily was defined based on the unexpected structural similarity of a protein domain present in families of cholesterol-dependent cytolysins (CDC) from bacteria and proteins of membrane attack complex/perforin (MACPF) family. Members of MACPF/CDC superfamily are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. Most known is their involvement in bacterial pathogenesis and proper functioning of the vertebrate immune system through formation of transmembrane pores in target cell membranes. This book for the first time brings together renowned researchers in the field of pore-forming proteins, structural biology and cellular and biophysical approaches to cover evolutionary, structural and functional aspects of this interesting superfamily of proteins. Book contains chapters on distribution of MACPF/CDC proteins and aspects on their evolution, structural properties and similarities between different members of the MACPF/CDC superfamily and functional properties of some of the most renowned members.


Pore Formation by MAPCF/CDC proteins- Agents of Defence, Attack and Invasion

Series: Subcellular Biochemistry, Vol. 80
Anderluh, Gregor; Robert Gilbert (Eds.)
Springer, New York ISBN 978-94-017-8881-6

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Proteins Membrane Binding and Pore Formation

There are currently only two structures of pores available, of alpha-toxin fromStaphylococcus aureus and hemolysin E from Escherichia coli. So what we know about these proteins was obtained over many years of intense experimentation. We have nevertheless, in the last couple of years, witnessed a significant rise in structural information on the soluble forms of pore-forming proteins. Surprisingly, many unexpected similarities with other proteins were noted, despite extremely low or insignificant sequence similarity. It appears that lipid membrane binding and formation of transmembrane channels is achieved in many cases by a limited repertoire of structures. This book describes how several of the important pore forming toxin families achieve membrane binding and which structural elements are used for formation of transmembrane pores. Our contributors have thus provided the means for a comparative analysis of several unrelated families.

Proteins Membrane Binding and Pore Formation

Series: Advances in Experimental Medicine and Biology, Vol. 677
Anderluh, Gregor; Lakey, Jeremy H. (Eds.)
Springer, New York ISBN: 978-1-4419-6326-0

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BOOK CHAPTERS

  1. Anderluh G, Menestrina G (2001) Pore-forming proteins from sea anemones and the construction of immunotoxins for selective killing of harmful cells. In: Recent advances in marine biotechnology. Vol. 6, Bio-organic compounds: chemistry and biomedical applications (Fingerman M, Nagabhushanam R, eds.). Enfield; Plymouth: Science Publishers, Inc., pages 131-148.
  2. Anderluh G, Maček P (2003) Actinoporins, pore-forming toxins of sea anemones (Actiniara). In: Pore-forming peptides and protein toxins: Cellular and molecular mechanisms of toxin action (Menestrina G, Dalla Serra M, eds.). London; New York: Taylor and Francis, pages 132-147. 
  3. Anderluh G, Lakey JH (2005) Lipid interactions of alpha-helical protein toxins. In: Protein-lipid interactions: from membrane domains to cellular networks (Tamm, LK, ed.). Weinheim: Wiley-VCH, pages 141-162. 
  4. Lakey JH, Anderluh G (2010) Membrane disrupting proteins. In: Handbook of hydrocarbon and lipid microbiology (Timmis, KW, ed.). Berlin; Heidelberg: Springer, pages 425-433.
  5. Bakrač B, Anderluh G (2010) Molecular mechanism of sphingomyelin-specific membrane binding and pore formation by actinoporins. In: Proteins membrane binding and pore formation (Advances in experimental medicine and biology, Vol. 677) (Anderluh G, Lakey JH, eds.). New York: Springer, 2010, pages 106-115. 
  6. Podlesnik Beseničar M, Anderluh G (2010) Preparation of lipid membrane surfaces for molecular interaction studies by surface plasmon resonance biosensors. In: Surface plasmon resonance : methods and protocols, (Methods in molecular biology, vol. 627) (De Mol NJ, Fischer MJE, eds.). New York: Springer, pages 191-200. 
  7. Hodnik V, Anderluh G (2010) Capture of intact liposomes in Biacore sensor chips for protein-membrane interaction studies. In: Surface plasmon resonance : methods and protocols, (Methods in molecular biology, vol. 627) (De Mol NJ, Fischer MJE, eds.). New York: Springer, pages 201-211.
  8. Bavdek A, Podlesnik Beseničar M, Maček P, Anderluh G (2010) Extraction of cholesterol from lipid membranes by methyl-beta-cyclodextrin: a surface plasmon resonance approach. In: Cyclodextrins: chemistry and physics (Hu J, ed.). Transworld Research Network, Kerala, 47-59.
  9. Hodnik V, Anderluh G (2013) Surface plasmon resonance for measuring interactions of proteins with lipid membranes. In: Lipid-protein interactions: methods and protocols (Kleinschmidt J, ed.). Springer protocols, Humana Press, New York, 23-36. 
  10. Cajnko MM, Mikelj M, Turk T, Podobnik M, Anderluh G (2014) Membrane interactions and cellular effects of MACPF/CDC proteins. In: MACPF/CDC Proteins - Agents of Defence, Attack and Invasion (Anderluh G, Gilbert RJ, eds.). Springer, 119-144. 
  11. Anderluh G, Kisovec M, Kraševec N, Gilbert RJ (2014) Distribution of MACPF/CDC proteins. In: MACPF/CDC Proteins - Agents of Defence, Attack and Invasion (Anderluh G, Gilbert RJ, eds.). Springer, 119-144. 
  12. Rojko N, Zanetti M, Anderluh G, Dalla Serra M (2015) Properties of Pores Formed by Cholesterol-Dependent Cytolysins and Actinoporins. In: Electrophysiology of Unconventional Channels and Pores (Delcour AH, ed.). Springer, Heidelberg, 267-286. 
  13. Vezočnik V, Hodnik V, Anderluh G (2017) Surface plasmon resonance analysis of food toxins and toxicants. In: Analysis of food toxins and toxicants (Wong YC, Lewis RJ, eds.). John Wiley & Sons., 195-216. doi: 10.1002/9781118992685.ch7.
  14. Šakanovič A, Hodnik V, Anderluh G (2019) Surface Plasmon Resonance for Measuring Interactions of Proteins with Lipids and Lipid Membranes. In: Lipid-Protein Interactions (Kleinschmidt J, ed.). Series: Methods in Molecular Biology. Springer, 53-70.